10.3389/fgene.2019.01409.s001 Guo-Hui Tang Guo-Hui Tang Xue Chen Xue Chen Jian-Cheng Ding Jian-Cheng Ding Jun Du Jun Du Xiao-Ting Lin Xiao-Ting Lin Lu Xia Lu Xia Jia-Bian Lian Jia-Bian Lian Feng Ye Feng Ye Xiu-Sheng He Xiu-Sheng He Wen Liu Wen Liu DataSheet_1_LncRNA LUCRC Regulates Colorectal Cancer Cell Growth and Tumorigenesis by Targeting Endoplasmic Reticulum Stress Response.pdf Frontiers 2020 colorectal cancer long non-coding RNA unfolded protein response cell growth therapeutic target 2020-01-31 04:54:17 Dataset https://frontiersin.figshare.com/articles/dataset/DataSheet_1_LncRNA_LUCRC_Regulates_Colorectal_Cancer_Cell_Growth_and_Tumorigenesis_by_Targeting_Endoplasmic_Reticulum_Stress_Response_pdf/11776290 <p>Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide, and is well known for its strong invasiveness, rapid recurrence, and poor prognosis. Long non-coding RNAs (lncRNAs) have been shown to be involved in the development of various types of cancers, including colorectal cancer. Here, through transcriptomic analysis and functional screening, we reported that lncRNA LUCRC (LncRNA Upregulated in Colorectal Cancer) is highly expressed in colorectal tumor samples and is required for colorectal cancer cell proliferation, migration, and invasion in cultured cells and tumorigenesis in xenografts. LUCRC was found to regulate target gene expression of unfolded protein response (UPR) in endoplasmic reticulum (ER), such as BIP. The clinical significance of LUCRC is underscored by the specific presence of LUCRC in blood plasma of patients with colorectal cancers. These findings revealed a critical regulator of colorectal cancer development, which might serve as a therapeutic target in colorectal cancer.</p>