10.3389/fgene.2019.01409.s001
Guo-Hui Tang
Guo-Hui
Tang
Xue Chen
Xue
Chen
Jian-Cheng Ding
Jian-Cheng
Ding
Jun Du
Jun
Du
Xiao-Ting Lin
Xiao-Ting
Lin
Lu Xia
Lu
Xia
Jia-Bian Lian
Jia-Bian
Lian
Feng Ye
Feng
Ye
Xiu-Sheng He
Xiu-Sheng
He
Wen Liu
Wen
Liu
DataSheet_1_LncRNA LUCRC Regulates Colorectal Cancer Cell Growth and Tumorigenesis by Targeting Endoplasmic Reticulum Stress Response.pdf
Frontiers
2020
colorectal cancer
long non-coding RNA
unfolded protein response
cell growth
therapeutic target
2020-01-31 04:54:17
Dataset
https://frontiersin.figshare.com/articles/dataset/DataSheet_1_LncRNA_LUCRC_Regulates_Colorectal_Cancer_Cell_Growth_and_Tumorigenesis_by_Targeting_Endoplasmic_Reticulum_Stress_Response_pdf/11776290
<p>Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide, and is well known for its strong invasiveness, rapid recurrence, and poor prognosis. Long non-coding RNAs (lncRNAs) have been shown to be involved in the development of various types of cancers, including colorectal cancer. Here, through transcriptomic analysis and functional screening, we reported that lncRNA LUCRC (LncRNA Upregulated in Colorectal Cancer) is highly expressed in colorectal tumor samples and is required for colorectal cancer cell proliferation, migration, and invasion in cultured cells and tumorigenesis in xenografts. LUCRC was found to regulate target gene expression of unfolded protein response (UPR) in endoplasmic reticulum (ER), such as BIP. The clinical significance of LUCRC is underscored by the specific presence of LUCRC in blood plasma of patients with colorectal cancers. These findings revealed a critical regulator of colorectal cancer development, which might serve as a therapeutic target in colorectal cancer.</p>