10.3389/fimmu.2019.02917.s001 Lea-Christina Kaminski Lea-Christina Kaminski Mathias Riehn Mathias Riehn Annemieke Abel Annemieke Abel Christiane Steeg Christiane Steeg Denis Dekugmen Yar Denis Dekugmen Yar Otchere Addai-Mensah Otchere Addai-Mensah Francis Aminkiah Francis Aminkiah Ellis Owusu Dabo Ellis Owusu Dabo Thomas Jacobs Thomas Jacobs Maria Sophia Mackroth Maria Sophia Mackroth Data_Sheet_1_Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria.PDF Frontiers 2019 granzyme B CD8+ T cells malaria severe malaria Plasmodium falciparum 2019-12-11 13:09:36 Dataset https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Cytotoxic_T_Cell-Derived_Granzyme_B_Is_Increased_in_Severe_Plasmodium_Falciparum_Malaria_PDF/11353400 <p>In Plasmodium falciparum malaria, CD8<sup>+</sup> T cells play a double-edged role. Liver-stage specific CD8<sup>+</sup> T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8<sup>+</sup> T cells, on the other hand, contribute to the development of cerebral malaria in murine models of malaria. The role of CD8<sup>+</sup> T cells in humans during the blood-stage of P. falciparum remains unclear. As part of a cross-sectional malaria study in Ghana, granzyme B levels and CD8<sup>+</sup> T cells phenotypes were compared in the peripheral blood of children with complicated malaria, uncomplicated malaria, afebrile but asymptomatically infected children and non-infected children. Granzyme B levels in the plasma were significantly higher in children with febrile malaria than in afebrile children. CD8<sup>+</sup> T cells were the main T cell subset expressing granzyme B. The proportion of granzyme B<sup>+</sup> CD8<sup>+</sup> T cells was significantly higher in children with complicated malaria than in uncomplicated malaria, whereas the activation marker CD38 on CD8<sup>+</sup> T cells showed similar expression levels. This suggests a pathogenic role of cytotoxic CD8<sup>+</sup> T cells in the development of malaria complications in humans.</p>