%0 Generic %A Zhang, Lei %A Zou, Xia %A Xu, Yong %A Medland, Nick %A Deng, Liwei %A Liu, Yin %A Su, Shu %A Ling, Li %D 2019 %T Data_Sheet_1_The Decade-Long Chinese Methadone Maintenance Therapy Yields Large Population and Economic Benefits for Drug Users in Reducing Harm, HIV and HCV Disease Burden.docx %U https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_The_Decade-Long_Chinese_Methadone_Maintenance_Therapy_Yields_Large_Population_and_Economic_Benefits_for_Drug_Users_in_Reducing_Harm_HIV_and_HCV_Disease_Burden_docx/10287712 %R 10.3389/fpubh.2019.00327.s001 %2 https://frontiersin.figshare.com/ndownloader/files/18662958 %K methadone maintenance treatment %K human immunodeficiency virus %K hepatitis C %K mathematical model %K economic benefit %X

Objectives: We aimed to conduct a comprehensive evaluation of the population impact of methadone maintenance treatment (MMT) for its future program planning.

Methods: We conducted a literature review of the effects of MMT in China on HIV and HCV disease burden, injecting, and sexual behaviors and drug-related harm during 2004–2015. Data synthesis and analysis were conducted to obtain the pooled estimates of parameters for a mathematical model which was constructed to evaluate the effectiveness and cost-effectiveness of the program.

Results: Based on a review of 134 articles, this study demonstrated that MMT is highly effective in reducing crime-related, high risk sexual, and injecting behaviors. The model estimated US$1,037 m which was invested in MMT from 2004 to 2015 has prevented 29,463 (15,325–43,600) new HIV infections, 130,563 (91,580–169,546) new HCV infections, 10,783 (10,380–11,187) deaths related to HIV, HCV and drug-related harm, and 338,920.0 (334,596.2–343,243.7) disability-adjusted life years (DALYs). The costs for each prevented HIV infection, HCV infection, death, and DALY were $35,206.8 (33,594.8–36,981.4), $7,944.7 ($7,714.4–8,189.2), $96,193.4 (92,726.0–99,930.2), and $3,060.6 ($3,022.0–3,100.1) respectively.

Conclusion: The Chinese MMT program has been effective and cost-effective in reducing injecting, injecting-related risk behaviors and adversities due to HIV/HCV infection and drug-related harm among drug users.

%I Frontiers